Natural anti-allergic herbs and its pharmacological review aspects

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Shanjai S
Balasubramanian K
Joshi I


Allergies have been known to be an abnormally vigorous immune response in which the immune system fights off an allergen or antigen, initiating mast cells to release histamine into the blood. Substances that prevent mast cells from releasing histamine are considered antiallergic agents. The drugs utilized to treat allergy are mast cell stabilizers, steroids, anti-histamine, leukotriene receptor antagonists, and decongestants. Anti-histamine drugs have side effects such as drowsiness, confusion, constipation, difficulty urinating, blurred vision, etc. So the alternate for these drugs are the only from herbal source. The use of medicinal plants for the effective and safe management of diseases has recently received much attention. Various herbs are utilized for their antiallergic and anti-histaminic properties. Some of the herbs useful in the management of allergic reaction like Tinospora cordifolia, Adathoda vasica,  Nigella sativa L, Curcuma Longa     , Glycirrhiza glabra , Coriander (Coriandrum sativum L.),  Azadirachta indica,  Piper nigrum L  , Nigella sativa and Lawsonia inermis Linn. The review summarizes a wide variety of herbs and botanical ingredients with their common scientific names and pharmacological actions pertaining to anti-allergic reaction etc.

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How to Cite
S, S., K, B., & I, J. (2023). Natural anti-allergic herbs and its pharmacological review aspects. Journal of Traditional and Integrative Medicine, 5(4), 482-498. Retrieved from


1. Chakravarty, N. "The role of plasma membrane Ca++-Mg++ activated adenosine triphosphatase of rat mast cells on histamine release." Acta Pharmacol. Toxicol. (Copenh), 1980; 47(3): 223-235.
2. Chakravarty, N. Inhibition of histamine release from mast cells by nigellone. Ann. Allergy, 1993; 70(3): 237-242.
3. Chanock, S. J., Benna, R. M., Smith, Babior, B. M. "The respiratory burst oxidase. J. Biol. Chem., . 1994; 269(40): 24519-24522.
4. Choi, Y.H., Chai, O.H., Han, E.H., Choi, S.Y., Kim, H.T., Song, C.H. Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction. Anat. Cell Biol.; 2010 b; 43 (4):317-324
5. Choi, Y.H., Yan, G.H., Chai, O.H., Lim, J.M., Sung, S.Y., Zhang, X., Kim, J.H., Choi, S.H., Lee, M.S., Han, E.H., Kim, H.T., Song, C.H. Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus.Biol Pharm Bull.; 2006; 29 (7):1360-1365.
6. Cluzel, M., Damon, M., Chanez, P. Enhanced alveolar cell luminol-dependent chemiluminescence in asthma. J. Allergy Clin. Immunol., 1987; 80, 195–201.
7. Costantin, L. L., Franzini-Armstrong, C., Podolsky, R. J. Localization of Calcium-Accumulating Structures in Striated Muscle Fibers. Science, 1965; 147: 158-160.
8. Crow, J., Beckman, J. The role of peroxynitrite in nitric oxide mediated toxicity. Curr. Top. Microbiol. Immunol., 1995, 196: 57-73.
9. EL-Dakhakhany, M. Some pharmacological properties of some constituents of Nigella sativa L seeds: The carbonyl fraction of essential oil. In: Proceedings of the 2nd International Conference on Islamic Medicine, Kuwait, 1982; 426–431.
10. El-Dakhakhny, M., Barakat, M., El-Halim, M. A., Aly, S. M. Effects of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. J. Ethnopharmacol., 2000; 72 (1-2): 299-304.
11. El Gazzar, M., El Mezayen, R., Marecki, J. C., Nicolls, M. R., Canastar, A. , Dreskin, S. C. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int. Immunopharmacol., 2006; 6(7): 1135-1142.