A Review on External and Internal Treatment for Eli Kadi (Rat Bite) in Selected Siddha Classical Literature

Dr. Gunapriya k*1 , Dr. Thiruthani M2 , Dr. Rajarajeshwari A3

1 PG Scholar, Department of Nanju Maruthuvam, 2 Proffesor Head of the Department, Department of Nanju Maruthuvam, 3 Lecturer, Research Methodology and Biostatistics, Government Siddha Medical College, Palayamkottai, Tirunelveli, Tamilnadu, India.

* Corresponding Author

ABSTRACT

Siddha system of medicine is a unique system which has been flourished with a wide range of treatment methods and provide definite cure to vast number of diseases. The siddhars had provided us with the knowledge in the field of toxicology and provided the treatment and cure to a wide range of toxins ranging from plant biotoxins to animal biotoxins as such the bites of rats, dogs, spider, scorpion, monkey, snakes, cats etc., in the literature. According to survey report of India by NCBI, about 15 million people are bitten by animals every year and around 25000 - 30000 deaths occurs in India due to animal bites in a year. Rat bite is one among these animal bites, which encounter the rural India as victim. Not all the rat bites cause serious issues but some of the infected rat bites may cause infectious diseases like Rat-bite fever, Plaque, Hanta virus infection, Leptospirosis which may proven as fatal in the history. In this research to explore the world about the ancient Siddha management of Rat Bite. Rats are named as Eli, Mooshika which are 18 in types. This research result was recorded as; 70 plants listed as internal and external medicine by siddha management process. In internal medicine Hard paste ( Karkam), Powder (Chooranam), Decoction (kudineer), Fresh juice (Saaru) was most commonly used and externally Paste (Poochu), Nasal medication (Nassiyam) were most commonly prescribred for the management of Rat bite. The most used plant parts are Root, leaves, barks, seeds, whole plant. Treatment of rat poisoning can be given in the diseases where the source of infection is rat since the symptoms are having similarity. This research concluded as to need a clinical assessment of siddha management in modern scientific way and introducing to global level in future.

KEYWORDS: Eli kadi, Siddha Toxicology, Siddha management, External medicine, Internal medicine, Rat bite diseases.

INTRODUCTION

Siddha system of medicine is a unique system which has been flourished with a wide range of treatment methods and provide definite cure to vast number of diseases. The siddhars had provided us with the knowledge in the field of toxicology as such how the toxins affect the human body and also provided the treatment and cure to a wide range of toxins ranging from plant biotoxins to animal biotoxins as such the bites of rats, dogs, spider, scorpion, monkey, snakes, cats etc., in the literature. According to survey report of India by NCBI, about 15 million people are bitten by animals every year and around 25000 - 30000 deaths occurs in India due to animal bites in a year. Rat bite is one among these animal bites, which encounter the rural India as victim. Not all the rat bites cause serious issues but some of the infected rat bites may cause infectious diseases like Rat-bite fever, Plaque, Hanta virus infection, Leptospirosis which may proven as fatal in the history.

Rats are named as Eli, Mooshika mentioned in Visha Vaithiya Sindhamani and Visha Vaithiya Aaruda Noolgal the ancient Siddha literatures. Rat are eighteen in types as per Siddha text they are Kathiri, Maniyan, Semmookkan, Valli, Kurattai, Karungkaatralaiyan, Vidaveli, Senthalaimuthi, Sevveli, Veengeli, Ularppeli, Thungeli, Pudaiyeli, Eraippeli, Sengkannan, Pulli, Kaadan, Kurungaleli. There are five modes of spread of rat (eli) poison. Semen, faeces, urine, scratches by nails and bites with teeth of rat are poisonous. Rat (eli) semen is the most poisonous and contact with this secretion can cause ill effects by the contamination in semen.

Symptoms of Rat Bite:

Fever with rigor, cough, dysnea, vitiation of blood, wheezing, lumps, pallor, arthralgia, increased body temperature, horripilation, vomiting, salivation, giddiness, loss of taste, thirst, pain at bite site, hoarseness of voice, blackish discoloration, small eruptions on the body.

Incurable Symptoms of Rat Bite:

Fainting, oedema all over the body, skin discoloration, recurrent fever, heaviness of head, excess of salivation, exudation, loss of hearing, haematemesis, urine retention, small nodules over the body resembling rat, body emitting smell of rat.

MODERN ASPECT

The Rattus genus has 64 species worldwide that make up a massive, uncountable population. Rats are from the order Rodentia which are characterized by an uncontrollable urge to gnaw. This is because the rats and others in this order have a pair of upper and lower teeth that grow nonstop, and the gnawing process files back the teeth to a manageable length. If they don’t gnaw frequently, the teeth will grow until they starve to death or are too weak to flee a predator.

Rat , (genus Rattus), the term generally denotes numerous members of several rodent families having bodies longer than about 12 cm, or 5 inches. (Smaller thin-tailed rodents are just as often referred to as mice.) The brown rat, Rattus norvegicus (also called the Norway rat), and the house rat, R. rattus (also called the black rat, ship rat, or roof rat), live virtually everywhere that human populations have settled; the house rat is predominant in warmer climates, and the brown rat dominates in temperate regions, especially urban areas. The house rat most likely originated in India.

Description: D:\rat picture\Roof_Rat.jpg

Description: D:\rat picture\Norway_Rat.jpg

Taxonomy

Kingdom: Animalia

Phylum: Chordata

Subphylum: Vertebrata

Class: Mammalia

Order: Rodentia

Superfamily: Muroidea

Family: Muridae

Subfamily: Murinae

Genus: Rattus

Rat Distribution:

Rats are found in all of the contiguous 48 states. They are also known to inhabit every land mass. The rat species is the most prolific invasive species worldwide.

Transmission of diseases

Mode of transmission of diseases:

Rats are an example of urban pest that transmit disease by several mechanisms, directly by contaminating food with their urine or faeces. Sometimes they transmit disease indirectly, as when fleas bite a disease infected rat, then a person or by biting people. Rat bites may cause local bacterial infection, which have good prognosis. Organisms recovered from bite wounds generally originate from the oral cavity of the biting animal, as well as from the patient's skin flora. Anaerobes have been isolated from bite wound infections, especially those associated with abscess formation.

Brown and house rat have been implicated in the spread of 40 diseases among humans, including bubonic plague, food poisoning, schistosomiasis, murine typhus, tularemia, and leptospirosis. On the other hand, the brown rat has been used in laboratories worldwide for medical, genetic, and basic biological research aimed at maintaining and improving human health. Rats are also kept as pets.

Diseases caused by rats

The common diseases that are caused by rats are:

· Hantavirus Pulmonary Syndrome

· Hemorrhagic Fever with Renal Syndrome

· Lymphocytic Chorio-meningitis (LCM)

· South American Arena viruses (Argentine hemorrhagic fever, Bolivian hemorrhagic fever, Sabiá-associated hemorrhagic fever, Venezuelan hemorrhagic fever)

Description: D:\rat picture\hanta2.jpg Description: D:\rat picture\a31c456e202eeddb76c814d41f67f916c8865f90-1110x720.jpg

Description: D:\rat picture\545b8a6980d65dbbf1c07abee8b30ad1b594c0f6-1110x720.jpg

Description: D:\rat picture\leptospirosis-infographics-leptospirosis-about-symptoms-prevention-health-concept-vector-cartoon-illustration_27170-178.jpg

Treatment:


Antibiotics such as cephalosporins or penicillinase-resistant penicillins are usually adequate for treatment of infectious complications of rat bites. Immunization against tetanus and rabies is also indicated, though rabies is rare after a rat bite. Wound management includes cleaning, debridement of tissue.

Penicillin is the treatment of choice for proven or highly suspected cases of rat bite fever. Tests of S. moniliformis antibiotic susceptibility by the disk diffusion method usually demonstrate sensitivity to penicillins, cephalosporins, carbapenems, aztreonam, clindamycin, erythromycin, nitrofurantoin, bacitracin, tetracycline, teicoplanin, and vancomycin; intermediate susceptibility to aminoglycosides, fluoroquinolones, and chloramphenicol; and resistance to trimethoprim-sulfamethoxazole, polymyxin B, and nalidixic acid.

AIM

This research work is aimed to explore the siddha management for Rat bite as per Siddha literature.

MATERIALS AND METHODS

STUDY TYPE : Literature review

REFERENCES :

From the ancient Siddha literature texts are, Sarabendrar Vaithiya Muraigal 1, Visha Vaithiya Aaruda Noolgal2, Pulippaani Vaithiyam 5003, Visha Vaithiya Sindhamani4 , Visha vaithiyam (vaithiya kalanidhi)5, Agasthiyar Mani 4000 (part 2) 6

TREATMENT OF RAT (ELI) BITE

Siddha classical literature had a wide collection of medicines ranging from herbal, herb mineral, herbometallic, herbo animal drugs to treat rat bites. Various drug preparations said in Siddha literature such as Karkam (hardpaste of drug), Kudineer (decoction), Saaru (Juice),Thailam(medicated oil), Nei(medicated ghee),Chooranam(Powder), Nasiyam(nasal medication), Poochu(paste), Kalikkam(collyrium) for rat bite.

EXTERNAL TREATMENT:

· Cauterization and blood letting from bite should be done.

· Paste of manjal (Curcuma longa), parpadagam (Mullugo cerviana) grinded with ghee should be applied on bite site.

· Paste of thagarai (Senna tora) seeds grinded with milk should be applied on bite site.

· Paste of amukkara (Withania somnifera) tuber grinded with water should be applied on bite site.

· Bark of aadhalai (Jatropha curcas) grinded with cow milk made as paste and applied on the bite site.

· Paste of pirandai (Cissus quadrangularis) should be applied on bite site.

· Leaf of vaeliparuthi (Pergularia daemia) along with latex of erukku (Calotropis gigantean) should applied on the bite site.

· Medicated oil: Ramabana Thylam external application4.

· Nasal Medication( Nasiyam):

Ø extract from the leaf of midhipagal (Momordica dioica), poondu (Allium sativum), vasambu (Acorus calamus) are used for nasal administration.

Ø Juice from paruthi (Gossypium herbaceum) leaves and gingilly oil used for nasal administration.

Ø Thurusu (Copper sulphate), seeds of azhingil (Alangium salviifolium) and murungai (Moringa oleifera), oil cake of iluppai (Madhuca longifolia), juice of lemon (Citrus limon) are used for making collyrium.

Ø Paranjodhi mai 4

Table 1. Symptomatic management of Rat Bite

S.NO

SYMPTOMS OF RAT BITE

MANAGEMENT

TYPE OF MEDICINE

1

Fever with rigor

Powder of Sensanthanam (Santalum album) and Thippili (Piper longum) along with honey

Internal

2

Cough

Powder of Koraikizhangu (Cyperus rotundus) with honey

Internal

3

Wheezing

Hard paste of Nayuruvi (Achyranthes aspera) whole plant

Internal

4

Breathlessness

Hard paste of Sankan (Azima tetracantha) root and kakkatan (Clitoria ternatea) root with milk

Internal

5

Bleeding gums and Toothache

Hard paste of Avuri (Indigofera tinctoria) root with milk for 7 days

Internal

6

Lumps

Powder of Perumaram (Ailanthus excelsa) bark and leaves with butter for 12 days

Internal

7

Increase of body temperature

Powder of Saaranai (Trianthema portulacastrum) root with milk

Internal

8

Arthritic pain of limbs

Powder of Amukkara (Withania somnifera) with honey

Internal

9

Paralysis of limb

Powder of Avuri (Indigofera tinctoria) root and sankan (Azima tetracantha) root

Internal

10

Inflammation of the body and fever

Hard paste of kaakattan (Clitoria ternatea) with butter milk

Internal

11

Oedema over the body

Palm jaggery with 7 drops of vellerukkam (Calotropis gigantean) milk for 7 days

Internal

12

Swelling

Fresh juice of Avuri

External

13

Blackish discoloration, patches

Powder of Aadutheenda paalai(Aristolochia bracteolate) root and sankan (Azima tetracantha) root for 12 days

Internal

14

Development of tumour, Constriction of eye, Ulceration,Itching

Powder of Chitramoolam (Plumbago zeylanica), Sivanarvembu (Indigofera aspalathoides), Kudasappaalai (Holarrhena pubescens), Vellarugu (Enicostema axillare)

Internal

15

Cough, Bronchitis, Congestion, Vomiting

Hard paste of Azhingil (Alangium salviifolium) rootbark for 8 days

Internal

16

Halitosis

Bark and seed of Vaazhai (Musa paradisica) grinded with honey should be given

Internal

17

Hematuria

Manjal (Curcuma longa) and Parpadagam (Mullugo cerviana) grinded with ghee made as hard paste should be given

Internal

18

Stomatitis, Stomach ache, Toothache

Palm jaggery with 8 drops of vellerukkam (Calotropis gigantean) milk for 7 days

Internal

19

Whitish discolaration of body and weakness of the body

Powder of Vaagai (Albizia lebbeck) seeds with honey

Internal

20

Salivation, Burning sensation, Swelling

Powder of Kadugu rogini (Picrorhiza kurroa) and crystal sugar

Internal

21

Blurring of vision

Root of Sirukeerai (Amaranthus tricolor) along with honey

Internal

Table.2 List of Medicinal plants used for Rat Bite

S.NO

PLANT NAME

BOTANICAL NAME

PART USED

FORMULATION OF MEDICINE

TYPE OF

MEDICINE

1

Oomathai

Datura metel

Leaves

Karkam

Internal

2

Amukkara

Withania somnifera

Root

Karkam

Internal

3

Pungam

Pongamia pinnata

Bark

Ooral neer

Internal

4

Murungai

Moringa oleifera

Leaves

Karkam

Internal

5

Naaval

Syzygium cumini

Root

Ooral neer

Internal

6

Paavattai

Pavetta indica

Root

Karkam

Internal

7

Peenari

Sterculia foetida

Bark

Karkam

Internal

8

Kaakkanam

Clitoria ternatea

Root

Karkam

Internal

9

Naralai

Cyphostemma setosum

Tuber

Chooranam

Internal

10

Avuri

Indigofera tinctoria

Root

Chooranam

Internal

11

Malligai

Jasminum grandifloram

Root

Chooranam

Internal

12

Erukku

Calotropis gigantea

Root

Ennai

Internal

13

Oomathai

Datura metel

Unripe fruit

Karkam

Internal

14

Alinchil

Alangium salviifolium

Bark

Chooranam

Internal

15

Kalapai kizhangu

Gloriosa superba

Rhizome

Ennai

Internal

16

Pirkku

Luffa acutangula

Seed

Ennai

Internal

17

Marudham

Terminalia arjuna

Bark

Pongal

Internal

18

Sivanvembu

Indigofera aspalathoides

Whole plant

Chooranam

Internal

19

Piraai

Strebulus asper

Bark

Kudineer

Internal

20

Veliparuthi

Pergularia daemia

Root

Karkam

Internal

21

Aadutheenda

Paalai

Aristolochia

bracteolate

Whole plant

Poochu

External

22

Iluppai

Madhuca longifolia

Oil cake

Karkam

Internal

23

Korai

Cyperus

Rotundus

Rhizome

Chooranam

Internal

24

Kudasapalai

Holarrhena pubescens

Bark

Chooranam

Internal

25

Katrazhai

Aloe vera

Gel

Kudineer

Internal

26

Sandhanam

Santalum album

Wood

Karkam

Internal

27

Parpadagam

Mullugo cerviana

Whole plant

Poochu

Internal & External

28

Erukku

Calotropis gigantea

Latex

Karkam

Internal

29

Thagarai

Senna tora

Seed

Karkam

Internal

30

Vaazhai

Musa paradisiaca

Fruit

Karkam

Internal

31

Vaagai

Albizia lebbeck

Seed

Chooranam

Internal

32

Punnai

Calophyllum inophyllum

Seed

Chooranam

Internal

33

Kaatamanakku

Jatropha curcas

Leaves

Karkam

Internal

34

Kodiveli

Plumbago zeylanica

Root

Kudineer

Internal & External

35

Veliparuthi

Pergularia daemia

Leaves

Saaru

Internal & External

36

Kadugurogini

Picrorhiza kurroa

Seed

Chooranam

Internal

37

Perunkayam

Ferula asafoetida

Resin

Poochu

Internal & External

38

Thippili

Piper longum

Seed

Karkam

Internal

39

Chukku

Zingiber officinale

Rhizome

Poochu

External

40

Saaranai

Trianthema portulacastrum

Tuber

Chooranam

Internal

41

Pirandai

Cissus quadrangularis

Root

Chooranam

Internal & External

42

Marul

Sansevieria roxburghiana

Tuber

Chooranam

Internal

43

Karuvelampattai

Acacia nilotica

Bark

Kudineer

Internal

44

Thavasu murungai

Sauropus androgynus

Leaves

Karkam

Internal

45

Sirukeerai

Amaranthus tricolor

Root

Karkam

Internal

46

Alinchil

Alangium salviifolium

Bark

Poochu

External

47

Kuppaimeni

Acalypha indica

Leaves

Poochu

External

48

Viizhi

Cadaba fruticosa

Root

Poochu

External

49

Midhipagal

Momordica dioica

Leaves

Saaru

External

50

Paruthi

Gossypium herbaceum

Leaves

Ennai

External

51

Kovai

Coccinia grandis

Bark

Karkam

Internal

52

Muththerukkan

Sevi

Helicteres isora

Leaves

Poochu

External

53

Uruthiratcham

Elaeocarpus serratus

Seed

Karkam

Internal

54

Nal velai

Cleome gynandra

Root

Saaru

External

55

Ilavangam

Syzygium aromaticum

Flower

Chooranam

Internal

56

Aththi

Ficus racemosa

Leaves

Saaru

Internal

57

Elumitchai

Citrus limon

Whole plant

Kudineer

Internal

58

Vembu

Azadirachta indica

Seed

Chooranam

Internal

59

Vellarugu

Enicostema axillare

Whole plant

Chooranam

Internal

60

Vasambu

Acorus calamus

Root

Karkam

Internal

61

Ulli

Allium sativum

Rhizome

Karkam

Internal

62

Perumaram

Ailanthus excels

Root

Chooranam

Internal

63

Sankan

Azima tetracantha

Root

Karkam

Internal

64

Naayuruvi

Achyranthes aspera

Whole plant

Chooranam

Internal

65

Vetrilai

Piper betle

Leaves

Karkam

Internal

66

Seenthil

Tinospora cordifolia

Leaves

Karkam

Internal

67

Malaiveppillai

Melia azedarach

Leaves

Saaru

Internal

68

Palaasu

Butea monosperma

Leaves

Karkam

Internal

69

Manjal

Curcuma longa

Rhizome

Poochu

External

70

Vaazhai

Musa paradisiaca

Bark

Saaru

Internal

Figure.1. TYPE OF MEDICINE

Figure. 2. PLANT PARTS USED FOR MEDICNE

Figure.3. FREQUENTLY USED PLANTS

DISSCUSSION

The review showed that there are 18 types of Rat found in Siddha literature . The most common symptoms are fever, cough, breathlessness, salivation, wheezing, fainting, shivering, arthralgia, vomiting, headache, thirst, skin discolartion, swelling as per siddha text. The symptoms of rat poisoning found in siddha text is correlated with the transmission of diseases to humans caused by rat such as Leptospirosis, Rat bite fever etc. The treatment of Rat poisoning can be given in the diseases where the source of infection is rat. From this research, the result was recorded as; 70 plants listed as internal(77%) and external medicine(23%) by siddha management . In internal medicine Hard paste (Karkam), Powder ( Chooranam), Decoction (kudineer), Fresh juice (Saaru) was most commonly used and externally Paste (Poochu), Nasal medication (Nassiyam) were most commonly prescribred for the management of Rat bite. The most used plant parts are Root, leaves, barks, seeds, whole plant. From the literature the more number of treatment said in siddha text of Sarabendra vaithiya muraigal, Visha vaithiya sindhamani, Visha vaithiya aaruda noolgal.

CONCLUSION

From this research Siddha classical literature had a many therapeutic formulation ranging from herbal, herbomineral, metallic drugs to treat rat bites. This documentation will help as a reference for emergency need and management care in case of rat bite. This study also provides valuable information for further research purpose and antidote studies. Therefore this research concluded as to need a clinical assessment of siddha management in modern scientific way and introducing to global level in future.

Text Box: Kabila eli Text Box: Veetu eli Description: D:\rat picture\Roof_Rat.jpg Text Box: Tree rat- mara eli Text Box: Bush rat- puthar eli Text Box: Jungle rat - kaateli Description: D:\rat picture\Norway_Rat.jpg

Description: D:\rat picture\hog-nosed-rat-data.jpg Description: D:\rat picture\Indian_Bush_Rat_at_Keoladeo_National_Park,_Bharatpur,_India.jpg Description: D:\rat picture\1200px-Black-tailed_Tree_Rat_(Thallomys_nigricauda)_with_young_(6854291852).jpg

Text Box: Roof rat- moeteli Text Box: Bristle rat- mul eli
Text Box: Field rat- vayal eli

Description: D:\rat picture\closeup-rat-feeding-field-260nw-1064888930.jpg Description: D:\rat picture\blackroofrat-alamy_500-t.jpg Description: D:\rat picture\bristlespined-rat-photographed-guarapari-santo-600w-1117661297.jpg

Text Box: Ridge rat- varapeli
Text Box: Antelope rat- sevveli

Description: D:\IMG-20201109-WA0000.jpg Description: D:\IMG-20201109-WA0001.jpg

Text Box: Pig rat - peruchali
Text Box: White rat – vella eli

Description: D:\rat picture\Greater-bandicoot-rat.jpg Description: D:\rat picture\white-albino-rat-baby-on-260nw-58462759.jpg

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