Hypolipidemic activity of Oorithal thaamarai chooranam (OTC) against Atherogenic diet-induced hyperlipidemia in experimental rats

Abstract

Hyperlipidemia  is a metabolic disorder characterized by loss of glucose homeostasis occurring due to defects in insulin secretion resulting from impaired metabolism of glucose, lipids and other energy yielding fuels such as lipids and proteins. It is a major endocrine disorder affecting nearly 10% of population all over the world. Currently several oral diabetic medications with different pharmacological actions  have been used. The adverse effects of this  medicines including impairment of gastrointestinal function,  hypoglycaemia and liver dysfunction. The usage  of the Siddha medicine still an essential part of public care. Oorithal thaamarai chooranam (OTC)  is a traditional Siddha formulation which has a claim of reducing blood lipids  level in Siddha literature. Hence the main aim of the present research work is to evaluate the hypolipidemic  potential of the Siddha drug OTC in rat model.