Preclinical and Clinical efficacy of Siddha drug Karisalankanni Chooranam in the management of Pandu noi (Iron Deficiency Anaemia)

Abstract

Siddha system is said to be one among the Indian system of medicines which deals with Five Boodhas and Three Humours in the diagnosing and treatment aspect of a disease. Siddhars classified diseases as 4448 types. PaanduNoi is one among them. Paandunoi symptoms are more or less equivalent to Iron deficiency anaemia. Iron Deficiency Anaemia (IDA) is a very common disease prevalent in the society. Long term oral iron therapy is commonly used as first line therapy but iron salts such as ferrous sulphate are associated with a high incidence of gastrointestinal side effects such as nausea, vomiting, diarrhoea or constipation. Because of their adverse effects, a safe, effective, cheap, and easily available drug is needed. Many drugs are available in Siddha system of medicine which have remarkable effects in treating anaemia. One such medicine is Karisalankannichooranam is indicated for anaemia mentioned in Siddha classical literature.

With the aim of that, this Poly Herbal preparation may be effective to manage childhood IDA without any synergistic effects. The present study was carried out to study the efficacy and safety of the Siddha poly herbal compound drug karisalankannichooranam with the application of modern parameters.  The Karisalankannichooranam reveal no toxicity in the preclinical studies and hence proven to be safe for human administration.

From the pre- clinical pharmacological study it is evident that the trial medicine has significant Haematinic action. Also Karisalankannichooranam has been proved clinically. Since as it raises the haemoglobin level in a marked level to the patients given regularly for not less than 30 days along with supplementary diets. Both symptomatic and qualitative improvement were absorbed. For prognosis, routine haematological investigation was taken. During the treatment no adverse events were observed. Statistically it has been proved that it shows significant raise in the haemoglobin level.